HS38 | DAPK1/DAPK3 inhibitor | Probechem Biochemicals

Chemical Structure : HS38

CAS No.: 1030203-81-6

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HS38 (HS-38)

货号: PC-62870Not For Human Use, Lab Use Only.

HS38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

HS38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
HS38 also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR.
HS38 decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation.
HS38 also promotes relaxation in Ca(2+)-sensitized vessels.

物理化学性质&存储条件

分子量	349.793
分子式	C14H12ClN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide

参考文献

1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23.

2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan;89(1):105-17.

HS38 (HS-38)

生物&药学活性

物理化学性质&存储条件

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HS38 (HS-38)

生物&药学活性

物理化学性质&存储条件

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