HS-1793 | 14-3-3 inhibitor | Probechem Biochemicals

Chemical Structure : HS-1793

CAS No.: 927885-00-5

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HS-1793 (HS1793)

货号: PC-38502Not For Human Use, Lab Use Only.

HS-1793 is a resveratrol derivative that overcomes the resistance conferred by Bcl-2 in U937 cells via 14-3-3, exhibits antitumor activity via Bad and marked downregulates 14-3-3 protein.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

HS-1793 is a resveratrol derivative that overcomes the resistance conferred by Bcl-2 in U937 cells via 14-3-3, exhibits antitumor activity via Bad and marked downregulates 14-3-3 protein.
HS-1793 induced polyploid LNCaP prostate cancer cells are vulnerable to downregulation of Bcl-xL.
HS1793 disrupts the interaction between AKT and heat shock protein 90 and induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells.
HS1793 inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells.

物理化学性质&存储条件

分子量	252.269
分子式	C16H12O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-Hydroxy-2-naphthalenyl)1,3-benzenediol

参考文献

1. Kim DH, et al. Int J Oncol. 2013 Dec;43(6):1915-24.

2. Jeong SH, et al. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4225-9.

3. Jeong SH, et al. Mol Cells. 2012 Oct;34(4):357-65.

4. Jeong SH, et al. Biochem Pharmacol. 2009 Apr 15;77(8):1337-47.

HS-1793 (HS1793)

生物&药学活性

物理化学性质&存储条件

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HS-1793 (HS1793)

生物&药学活性

物理化学性质&存储条件

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