HQY426 | CPSF3 inhibitor | Probechem Biochemicals

Chemical Structure : HQY426

CAS No.:

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HQY426 (HQY 426)

货号: PC-21416Not For Human Use, Lab Use Only.

HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity.

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5 mg	￥3980	In stock
10 mg	￥5580	In stock
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生物&药学活性

HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity.
HQY426 suppresses cell proliferation and causes G2-M arrest and apoptosis in ovarian cancer cells.
HQY426 (10 mg/kg per day) exhibits potent therapeutic efficacy and low systemic toxicity in SKOV3 xenografts BALB/c nude mice.
HQY426 effectively exacerbated genomic instability by down-regulating DNA damage repair genes and thus acted in synergy with poly(adenosine 5'-diphosphate–ribose) polymerase inhibition.

物理化学性质&存储条件

分子量	366.22
分子式	C20H23BN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)-N-(3-morpholinophenyl)propanamide

参考文献

1. Shen P, et al. Sci Adv. 2023 Nov 24;9(47):eadj0123.

HQY426 (HQY 426)

生物&药学活性

物理化学性质&存储条件

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HQY426 (HQY 426)

生物&药学活性

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