HOSU-53 acid | DHODH inhibitor | Probechem Biochemicals

Chemical Structure : HOSU-53 acid

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HOSU-53 acid (HOSU53 )

货号: PC-22220Not For Human Use, Lab Use Only.

HOSU-53 acid is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.

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生物&药学活性

HOSU-53 acid is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays.
HOSU-53 shows relatively similar inhibitory potency across mouse, rat, and dog DHODH enzyme.
HOSU-53 displays little to no activity against a panel of approximately 450 human kinases at 10 μM.
HOSU-53 exhibits potent in vitro antileukemic activity with median IC50 of 120.5 nM, promotes in vitro innate phagocytic function.
HOSU-53 (30 mg/kg) demonstrates in vivo single-agent antileukemic activity, results in superior in vivo outcome using AML disseminated xenograft model.
HOSU-53 demonstrates in vivo synergy with approved targeted AML therapies.

物理化学性质&存储条件

分子量	415.46
分子式	C26H22FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3'-butoxy-[1,1'-biphenyl]-4-yl)-6-fluoroquinoline-4-carboxylic acid

参考文献

1. Ola A Elgamal, et al. JCI Insight. 2024 Apr 22;9(8):e173646.

HOSU-53 acid (HOSU53 )

生物&药学活性

物理化学性质&存储条件

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HOSU-53 acid (HOSU53 )

生物&药学活性

物理化学性质&存储条件

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