HOSU-53 (JBZ-001) | DHODH inhibitor | Probechem Biochemicals

Chemical Structure : HOSU-53

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HOSU-53 (HOSU53, JBZ-001)

货号: PC-24295Not For Human Use, Lab Use Only.

HOSU-53 (JBZ-001) is a potent and selective inhibitor of DHODH with IC50 of 0.95 nM (hDHODH), exhibits potent antileukemic activity.

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生物&药学活性

HOSU-53 (JBZ-001) is a potent and selective inhibitor of DHODH with IC50 of 0.95 nM (hDHODH), exhibits potent antileukemic activity.
HOSU-53 has similar inhibitory potency across against mouse, rat, and dog DHODH enzymes.
HOSU-53 shows no alternative-target activity at 10 μM against a panel of approximately 450 human kinases
HOSU-53 significantly reduced oxidative metabolism in T cells both during and after activation, while selectively suppressing inflammatory cytokine production in de novo activated, but not previously activated, T cells.
HOSU-53 treatment limited GVHD severity, decreased pathogenic Th1 and Th17 response, and preserved beneficial GVL effects in xenogeneic model.
HOSU-53 in combination with anti-CD47 therapy results in long-term disease-free survival in the MOLM-13 CDX AML in vivo model.
HOSU-53 shows in vivo efficacy superior to other DHODH inhibitors and exceptional pharmaceutical properties for clinical advancement.

物理化学性质&存储条件

分子量	437.45
分子式	C26H21FNNaO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 2-(3'-butoxy-[1,1'-biphenyl]-4-yl)-6-fluoroquinoline-4-carboxylate

参考文献

1. Kumar R, et al. J Immunol. 2025 Mar 22:vkaf023. doi: 10.1093/jimmun/vkaf023.

2. Elgamal OA, et al. JCI Insight. 2024 Apr 22;9(8):e173646.

HOSU-53 (HOSU53, JBZ-001)

生物&药学活性

物理化学性质&存储条件

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HOSU-53 (HOSU53, JBZ-001)

生物&药学活性

物理化学性质&存储条件

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