HNF4 agonist 46

Chemical Structure : HNF4 agonist 46

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货号: PC-24565Not For Human Use, Lab Use Only.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HNF4 agonist 46 is a first-in-class, high-affinity hepatocyte nuclear factor 4 (HNF4) agonist, activates HNF4α (EC50=6 nM) and HNF4γ (EC50=17 nM) with low nanomolar potency, binds to HNF4α LBD with ITC Kd of 23 nM.
HNF4 agonist 46 exhibits similar agonism on the highly related HNF4α and HNF4γ isoforms in cellular assays.
HNF4 agonist 46 displays favorable selectivity over other fatty acid/lipid sensing (THR, RAR, PPAR, VDR, LXR, FXR, RXR) and promiscuous (CAR, PXR) nuclear receptors at 1 uM.
HNF4 agonist 46 is a high-quality chemical tool to study HNF4 biology in vitro.

物理化学性质&存储条件

分子量	286.71
分子式	C16H11ClO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(2-Chloro-4-methylphenyl)ethynyl]-2-hydroxybenzoic Acid

参考文献

1. Schallmayer E, et al. J Med Chem. 2025 May 8. doi: 10.1021/acs.jmedchem.5c00595.

HNF4 agonist 46

生物&药学活性

物理化学性质&存储条件

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HNF4 agonist 46

生物&药学活性

物理化学性质&存储条件

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