Pynegabine (HN37) | Kv7.2/7.3 activator | Probechem Biochemicals

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-HN37

Chemical Structure : HN37

CAS No.: 1821222-10-9

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HN37 (Pynegabine)

货号: PC-27788Not For Human Use, Lab Use Only.

Pynegabine (HN37) is a novel, next-generation positive allosteric modulator/activator of KCNQ2/3 (Kv7.2/7.3) potassium with EC50 of 37 nM ( KCNQ2), shows antiepileptic activity.

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10 mg	￥3280	In stock
25 mg	￥5280	In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pynegabine (HN37) is a novel, next-generation positive allosteric modulator/activator of KCNQ2/3 (Kv7.2/7.3) potassium with EC50 of 37 nM ( KCNQ2), shows antiepileptic activity.

物理化学性质&存储条件

分子量	340.40
分子式	C20H21FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (4-((4-fluorobenzyl)(prop-2-yn-1-yl)amino)-2,6-dimethylphenyl)carbamate

参考文献

1. Yang-Ming Zhang, et al. J Med Chem. 2021 May 13;64(9):5816-5837.

2. Ma D, et al. Nat Commun. 2023 Oct 19;14(1):6632.

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HN37 (Pynegabine)

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物理化学性质&存储条件

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HN37 (Pynegabine)

生物&药学活性

物理化学性质&存储条件

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