HKC54

Chemical Structure : HKC54

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货号: PC-26458Not For Human Use, Lab Use Only.

HKC54 is a potent, selective TRPV2 antagonist with IC50 of 0.4 uM, 50-fold selectivity over TRPV1 and ∼70-fold selectivity over TRPA1.

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生物&药学活性

HKC54 is a potent, selective TRPV2 antagonist with IC50 of 0.4 uM, 50-fold selectivity over TRPV1 and ∼70-fold selectivity over TRPA1.
HKC54 (5-10 uM) inhibits cancer cell migration in U-251 WT cells, but not TRPV2 KD cells.
HKC54 (12.5 or 25 mg/kg every other day) produced a marked reduction in lung metastatic nodules, effectively inhibited tumor metastasis in Balb/c mice with breast cancer and 4T1-Luc2 lung metastasis.

物理化学性质&存储条件

分子量	344.37
分子式	C18H20N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-oxopiperidine-1-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

参考文献

1. Kiely-Collins H, et al. ACS Chem Biol. 2026 Mar 25. doi: 10.1021/acschembio.5c00935.

HKC54

生物&药学活性

物理化学性质&存储条件

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HKC54

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物理化学性质&存储条件

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