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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-HJC0416
HJC0416

Chemical Structure : HJC0416

CAS No.: 1617518-22-5

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HJC0416 (HJC-0416, HJC 0416)

货号: PC-60500Not For Human Use, Lab Use Only.

HJC0416 is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HJC0416 is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM.
    HJC0416 inhibits the proliferation of both ER-positive, and ER-negative (triple negative) breast cancer cells with IC50 values of 1.76 uM and 1.97 uM, respectively.
    HJC0416 inhibits cell cycle progression and promotes apoptosis both in vitro and in vivo.

    物理化学性质&存储条件

    分子量 392.854
    分子式 C18H17ClN2O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxo-1H-1λ6-benzo[b]thiophen-6-yl)benzamide

    参考文献

    1. Chen H, et al. Eur J Med Chem. 2014 Jul 23;82:195-203.

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