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首页-小分子抑制剂&激动剂-Others-Other Targets-HJC0350
HJC0350

Chemical Structure : HJC0350

CAS No.: 885434-70-8

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HJC0350 (HJC-0350)

货号: PC-44643Not For Human Use, Lab Use Only.

HJC0350 is a potent and specific EPAC2 antagonist with IC50 of 0.3 uM for competing with 8-NBD-cAMP in binding EPAC2, about 133-fold more potent than cAMP.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HJC0350 is a potent and specific EPAC2 antagonist with IC50 of 0.3 uM for competing with 8-NBD-cAMP in binding EPAC2, about 133-fold more potent than cAMP.
HJC0350 exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM.
HJC0350 selectively blocks cAMP-induced EPAC2 activation but does not inhibit cAMP-mediated PKA activation, fully blocks the 007-AM induced decrease of FRET in HEK293/EPAC2-FL cells at 10 uM.

物理化学性质&存储条件

分子量 277.38
分子式 C15H19NO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mM
Chemical Name/SMILES

1H-Pyrrole, 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-

参考文献

1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62.

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