HIF-PH inhibitor 13

Chemical Structure : HIF-PH inhibitor 13

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货号: PC-24485Not For Human Use, Lab Use Only.

HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2).
HIF-PH inhibitor 13 enhances hematopoietic stem cell (HSC) mobilization in combination with G-CSF.
HIF-PH inhibitor 13 is effective at enhancing G-CSF-induced HSC mobilization in mice at a dose of 2 mg/kg.

物理化学性质&存储条件

分子量	379.42
分子式	C20H21N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-cyclohexyl-4-hydroxy-8-oxo-N-(pyridazin-4-ylmethyl)-7,8-dihydro-2,7-naphthyridine-3-carboxamide

参考文献

1. Wu M, et al. J Med Chem. 2025 Mar 6. doi: 10.1021/acs.jmedchem.4c02889.