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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-HHT-9041P1
HHT-9041P1

Chemical Structure : HHT-9041P1

CAS No.:

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HHT-9041P1

货号: PC-27281Not For Human Use, Lab Use Only.

HHT-9041P1 is a potent and selective JAK1 inhibitor with IC50 of 612 nM, displays 10-, 23- and 63-fold selective over JAK2, JAK3 and TYK2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HHT-9041P1 is a potent and selective JAK1 inhibitor with IC50 of 612 nM, displays 10-, 23- and 63-fold selective over JAK2, JAK3 and TYK2.
HHT-9041P1 inhibits IL-6-induced phosphorylation of STAT1 and STAT3 in human CD3+ T cells and GM-CSF-induced STAT5 phosphorylation in CD14+ cells with IC50 of 0.078, 0.646 and 1.445 uM respectively.
HHT-9041P1 (1-10 mg/kg, p.o.) inhibits disease pathology in rat collagen-induced arthritis.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Xiaojuan Zhang, et al. Int Immunopharmacol. 2023 Dec;125(Pt A):111086.

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