HGC652 | TRIM21 ligand, Molecular glue degrader | Probechem Biochemicals

Chemical Structure : HGC652

加入收藏

HGC652 (HGC-652)

货号: PC-24423Not For Human Use, Lab Use Only.

HGC652 is an E3 ubiquitin ligase TRIM21-dependent molecular glue degrader (TRIM21 Kd=0.06 uM), induces TRIM21-NUP98 interaction and causes selective degradation of nuclear pore complex proteins.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HGC652 is an E3 ubiquitin ligase TRIM21-dependent molecular glue degrader (TRIM21 Kd=0.06 uM), induces TRIM21-NUP98 interaction and causes selective degradation of nuclear pore complex proteins.
HGC652 induced polyubiquitination of SmF-EGFP-SH3-NUP98APD and SmF-EGFP-PRM in CEBIT assays.
HGC652 also induced the formation of TRIM21-NUP98 complex as shown by the Strep-tag pull-down assays.
HGC652 demonstrated dose-dependent growth inhibition against 8 cancer cell lines with IC50 of 0.106-0.822 uM.

物理化学性质&存储条件

分子量	449.60
分子式	C23H28FNO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(cyclohexylmethyl)-4'-fluoro-N-methyl-3-(methylsulfonyl)-2'-(methylthio)-[1,1'-biphenyl]-4-carboxamide

参考文献

1. Li X, et al. ACS Chem Biol. 2025 Apr 18. doi: 10.1021/acschembio.4c00833.

2. Patent WO2024179572 A1.

3. Li, X, et al. Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21. bioRxiv 2024, DOI: 10.1101/2024.12.03.626577

HGC652 (HGC-652)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HGC652 (HGC-652)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.