HG043 | GPR119 agonist | Probechem Biochemicals

Chemical Structure : HG043

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HG043 (HG-043)

货号: PC-24686Not For Human Use, Lab Use Only.

HG043 is a potent thienopyrimidine-based GPR119 agonist with EC50 of 2.0 nM (human GPR119) in GPR119 CRE-bla CHO-K1 cells using a cAMP assay.

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生物&药学活性

HG043 is a potent thienopyrimidine-based GPR119 agonist with EC50 of 2.0 nM (human GPR119) in GPR119 CRE-bla CHO-K1 cells using a cAMP assay.
HG043 potently stimulates insulin secretion with an EC50 value of 0.1 nM from MIN6 mouse pancreatic β-cells, demonstrating approximately 100-fold higher potency compared to MBX-2982 (EC50 = 17.65 nM).
HG043 stimulates the secretion of GLP-1, Insulin, GIP, and PYY.
HG043 significantly enhances glycemic homeostasis in normal and diabetic rodents.
HG043 effectively reduces body weight, food intake, and fat mass in DIO rats.

物理化学性质&存储条件

分子量	517.59
分子式	C23H24FN5O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-((7-(2-fluoro-4-(methylsulfonyl)phenyl)thieno[3,2-d]pyrimidin-4-yl)oxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

参考文献

1. Kim H, et al. Eur J Med Chem. 2023 Oct 5;258:115584.

HG043 (HG-043)

生物&药学活性

物理化学性质&存储条件

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HG043 (HG-043)

生物&药学活性

物理化学性质&存储条件

参考文献

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