HDN2398 | IAV NS1 inhibitor | Probechem Biochemicals

Chemical Structure : HDN2398

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HDN2398 (HDN-2398)

货号: PC-28415Not For Human Use, Lab Use Only.

HDN2398 is a broad-spectrum influenza inhibitor that blocks multiple functions of viral NS1 protein, exhibits H1N1virusA/ Virginia/ATCC1/2009 inhibition (IC50=3.3 uM) in MDCK cells.

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生物&药学活性

HDN2398 is a broad-spectrum influenza inhibitor that blocks multiple functions of viral NS1 protein, exhibits H1N1virusA/ Virginia/ATCC1/2009 inhibition (IC50=3.3 uM) in MDCK cells.
HDN2398 significantly reduced the virus titer and plaque formation in A/Puerto Rico/8/34 (PR/8)-, A/Aichi/2/1968 (Aichi)-, and A/Virginia/ATCC1/2009 (Vir09)-infected cells in a dose-dependent manner, with IC50 values ranging from 2.6 to 7.7μM, which was superior to the effects of oseltamivir.
HDN2398 (2.5 or 5mg/kg/day, oral) significantly decreased pulmonary viral titers in mouse pneumonia model.
HDN2398 (25 µM) can markedly protect virus NS1 rather than NA protein from protease digestion especially under pronase treatment at 6μg/ml.
HDN2398 blocks the nuclear export of NS1 by interfering with its binding to nucleolin.
HDN2398 affects the mRNA splicing and nuclear export by blocking the binding of NS1 to NS1-BP and NXF1.
HDN2398 attenuates the interferon antagonistic function of NS1 by reducing the NS1-dsRNA interaction and the ubiquitination of RIG-I.

物理化学性质&存储条件

分子量	669.70
分子式	C38H36FNO9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1',1''-(((5-fluoro-1H-indole-1,2,3-triyl)tris(methylene))tris(2,4-dihydroxy-5-methylbenzene-3,1-diyl))tris(ethan-1-one)

参考文献

1. Yang Zhang, et al. Nat Commun. 2026 Sep 1;17(1):10417.

HDN2398 (HDN-2398)

生物&药学活性

物理化学性质&存储条件

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HDN2398 (HDN-2398)

生物&药学活性

物理化学性质&存储条件

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