HDM2004 | HPK1 inhibitor | Probechem Biochemicals

Chemical Structure : HDM2004

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HDM2004 (HDM-2004)

货号: PC-26106Not For Human Use, Lab Use Only.

HDM2004 is a potent, selective and orally bioavailable HPK1 (MAP4K1) inhibitor with IC50 of 1.89 nM, >30-fold selectivity over the closely related kinase GLK.

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生物&药学活性

HDM2004 is a potent, selective and orally bioavailable HPK1 (MAP4K1) inhibitor with IC50 of 1.89 nM, >30-fold selectivity over the closely related kinase GLK.
HDM2004 has IC50 of 38.9 nM on cytokine production in PBMC-IL-2 assays.
HDM2004 displays moderate kinome selectivity with potent "off target" kinase hits mainly include ROCK1, JAK3, JNK1, CLK1 and LCK, AXL and PKD2.
HDM2004 displayed synergistic antitumor activity when combined with PD-L1 blockade in syngeneic mouse models.

物理化学性质&存储条件

分子量	485.64
分子式	C28H35N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,6R)-4-(4-(7-(1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)phenyl)-2,6-dimethylmorpholine

参考文献

1. Zhimin Zhang, et al. Eur J Med Chem. 2026 Feb 20:308:118708.

HDM2004 (HDM-2004)

生物&药学活性

物理化学性质&存储条件

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HDM2004 (HDM-2004)

生物&药学活性

物理化学性质&存储条件

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