HDACi-4b |CAS:537034-15-4 Probechem Biochemicals

Chemical Structure : HDACi-4b

CAS No.: 537034-15-4

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HDACi-4b (NKL22;NKL-22)

货号: PC-42126Not For Human Use, Lab Use Only.

A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

HDACi-4b (NKL22) is a benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
HDACi-4b (NKL22) reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia.
HDACi-4b (NKL22) directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12).
HDACi-4b (NKL22) significantly improves motor performance, overall appearance, and body weight in an HD mouse model.

物理化学性质&存储条件

分子量	325.4048
分子式	C19H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-

参考文献

1. Jia H, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E56-64.

2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.

3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.

HDACi-4b (NKL22;NKL-22)

生物&药学活性

物理化学性质&存储条件

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HDACi-4b (NKL22;NKL-22)

生物&药学活性

物理化学性质&存储条件

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