HDAC11 inhibitor PB94 | HDAC11 inhibitor | Probechem Biochemicals

Chemical Structure : HDAC11 inhibitor PB94

CAS No.: 3032970-74-1

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HDAC11 inhibitor PB94 (PB94)

货号: PC-21403Not For Human Use, Lab Use Only.

HDAC11 inhibitor PB94 is a potent, selective and brain-permeable HDAC11 inhibitor with IC50 of 108 nM, >40-fold over other HDAC isoforms.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

HDAC11 inhibitor PB94 is a potent, selective and brain-permeable HDAC11 inhibitor with IC50 of 108 nM, >40-fold over other HDAC isoforms.
PB94 (20 uM) significantly increases the fatty acylation level of SHMT2 in HEK293T cells.
PB94 exhibits good brain permeability, with brain/plasma ratios of 2.3 at 30 min and 2.2 at 4 h postinjection.
PB94 (3-10 mg/kg) attenuates neuropathic pain and the CCI-induced microgliosis in mice.

物理化学性质&存储条件

分子量	487.60
分子式	C29H33N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(adamantan-1-ylmethyl)-1-(4-(hydroxycarbamoyl)-3-methoxybenzyl)-1H-indole-5-carboxamide

参考文献

1. Bai P, et al. J Med Chem. 2023 Nov 16. doi: 10.1021/acs.jmedchem.3c01491.

HDAC11 inhibitor PB94 (PB94)

生物&药学活性

物理化学性质&存储条件

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HDAC11 inhibitor PB94 (PB94)

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物理化学性质&存储条件

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