HD202A

Chemical Structure : HD202A

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货号: PC-26314Not For Human Use, Lab Use Only.

HD202A is a highly potent, selective MNK1/2 inhibitor with IC50 of 6.1/8.1 nM respectively.

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生物&药学活性

HD202A is a highly potent, selective MNK1/2 inhibitor with IC50 of 6.1/8.1 nM respectively.
HD202A displays marked selectivity for MNK1/2 across a 140-kinase panel.
HD202A suppressed MNK-eIF4E signaling, downregulated perilipin 2 and stearoyl-coenzyme A desaturase 1, upregulated adipose triglyceride lipase and peroxisome proliferator-activated receptor gamma coactivator 1α, and enhanced mitochondrial fatty-acid oxidation and redox homeostasis.
HD202A markedly reduced body-weight gain, hepatic triglyceride accumulation, and serum lipids while improving glucose tolerance, insulin sensitivity, and inflammatory profiles.

物理化学性质&存储条件

分子量	456.57
分子式	C25H24N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl)benzonitrile

参考文献

1. Qiu T, et al. J Med Chem. 2026 Mar 9. doi: 10.1021/acs.jmedchem.5c03316.

HD202A

生物&药学活性

物理化学性质&存储条件

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HD202A

生物&药学活性

物理化学性质&存储条件

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