HCY-NBD

Chemical Structure : HCY-NBD

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货号: PC-26078Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

HCY-NBD is a small molecule stabilizer of Glutathione S-transferase Mu 2 (GSTM2), promotes sulfenylation at Cys174 of GSTM2 and inhibits its K48-linked ubiquitination at this residue, stabilizes GSTM2 protein levels.
Cys174 is the critical residue for HCY-NBD-mediated regulation of GSTM2 sulfenylation and non-lysine ubiquitination.
HCY-NBD up-regulates GSTM2 inhibiting high-glucose-induced vascular endothelial cell senescence and calcification.
HCY-NBD up-regulates GSTM2 inhibiting vascular senescence and calcification in db/db mice.

物理化学性质&存储条件

分子量	636.49
分子式	C29H29IN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1,3,3-trimethyl-2-(4-(4-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)piperazin-1-yl)styryl)-3H-indol-1-ium iodide salt

参考文献

1. Yangyang Zhang, et al. Redox Biol. 2026 Mar:90:104058. doi: 10.1016/j.redox.2026.104058.

HCY-NBD

生物&药学活性

物理化学性质&存储条件

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HCY-NBD

生物&药学活性

物理化学性质&存储条件

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