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首页-小分子抑制剂&激动剂-Others-Midkine-HBS-101
HBS-101

Chemical Structure : HBS-101

CAS No.:

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HBS-101 (HBS101)

货号: PC-24528Not For Human Use, Lab Use Only.

HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.
    HBS-101 exhibits distinct pharmacologic advantages, including oral bioavailability, blood-brain-barrier penetration, and in vivo stability.
    The underlying mechanism of HBS-101 involves suppression of Akt/mTOR, STAT3, and NF-B pathways.
    HBS-101 inhibits growth of TNBC patient-derived xenograft tumors in vivo and markedly reduced TNBC brain-metastatic-tumor growth and prolonged mice survival.

    物理化学性质&存储条件

    分子量 346.42
    分子式 C21H24F2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (13S,17S)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

    参考文献

    1. Mahajan M, et al. Mol Cancer Ther. 2025 Apr 30. doi: 10.1158/1535-7163.MCT-25-0130.

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