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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-HAM-1
HAM-1

Chemical Structure : HAM-1

CAS No.:

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HAM-1

货号: PC-27908Not For Human Use, Lab Use Only.

HAM-1 is a small molecule modulator of Hsp90-Aha1 with KD app of 24 uM, binds to the Hsp90 N-domain, does not dissociate the Aha1-Hsp90 complex but prevents the specific interaction with the N-terminal domain of Hsp90 required for catalysis, affectes the activation and processing of Hsp90-Aha1-dependent client proteins in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HAM-1 is a small molecule modulator of Hsp90-Aha1 with KD app of 24 uM, binds to the Hsp90 N-domain, does not dissociate the Aha1-Hsp90 complex but prevents the specific interaction with the N-terminal domain of Hsp90 required for catalysis, affectes the activation and processing of Hsp90-Aha1-dependent client proteins in vivo.

物理化学性质&存储条件

分子量 416.39
分子式 C22H14F2N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-amino-3-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1H-pyrazol-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

参考文献

1. Stiegler SC, et al. J Biol Chem. 2017 Oct 13;292(41):17073-17083.

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