H052

Chemical Structure : H052

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货号: PC-24353Not For Human Use, Lab Use Only.

H052 is a highly potent S. aureus α-hemolysin (Hla) inhibitor, protect U937 cells from Hla-induced Ca2+ influx with EC50 of 0.01 uM, restores Hla-induced damage of host cell integrity.

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生物&药学活性

H052 is a highly potent S. aureus α-hemolysin (Hla) inhibitor, protect U937 cells from Hla-induced Ca2+ influx with EC50 of 0.01 uM, restores Hla-induced damage of host cell integrity.
H052 prevent the formation of functional pores by interacting with α-hemolysin.
H052 is active in mouse models of S. aureus lung infections, when administered prophylactically or therapeutically, either as monotherapy or when given in combination with the antibiotic linezolid.

物理化学性质&存储条件

分子量	459.88
分子式	C21H15ClFN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-4'-fluoro-[1,1'-biphenyl]-4-yl)-7-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide

参考文献

1. Aditya Shekhar, et al. Cell Host Microbe. 2025 Mar 25:S1931-3128(25)00089-7.

H052

生物&药学活性

物理化学性质&存储条件

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H052

生物&药学活性

物理化学性质&存储条件

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