H018 | JAK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : H018

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H018 (RAI-20)

货号: PC-26282Not For Human Use, Lab Use Only.

H018 (RAI-20) is a highly potent, selective JAK1/2 inhibitor with IC50 of 15.1/22.7 nM, >10-fold and 20-fold selective over JAK3 amd TYK2, displays robust anti-arthritic efficacy.

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生物&药学活性

H018 (RAI-20) is a highly potent, selective JAK1/2 inhibitor with IC50 of 15.1/22.7 nM, >10-fold and 20-fold selective over JAK3 amd TYK2, displays robust anti-arthritic efficacy.
H018 (RAI-20) shows inhibitory activity against Ba/F3 cells with IC50 of 1.21 uM, nearly 6 times more potent than Filgotinib.
H018 (RAI-20) inhibits the expression of pSTAT1 induced by IL-6 with IC50 of 1.45 uM in human whole blood.
H018 (RAI-20) (2, 3, 5, and 10 mg/kg) significantly reduced the hind paw volume in CIA model.

物理化学性质&存储条件

分子量	448.53
分子式	C20H21FN4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopropanecarboxamide, N-[5-[5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-thienyl]imidazo[1,2-a]pyridin-2-yl]-2-fluoro-, (1R,2S)-rel-

参考文献

1. Haifeng Zhu, et al. Eur J Med Chem. 2026 Mar 2:309:118729.

2. Patent CN111892592 A 2020-11-06.

H018 (RAI-20)

生物&药学活性

物理化学性质&存储条件

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H018 (RAI-20)

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物理化学性质&存储条件

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