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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-H-1152
H-1152

Chemical Structure : H-1152

CAS No.: 451462-58-1

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H-1152 (H 1152, H1152)

货号: PC-44656Not For Human Use, Lab Use Only.

H-1152 is a potent and selective ROCK inhibitor with Ki of 1.6 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

H-1152 is a potent and selective ROCK inhibitor with Ki of 1.6 nM.
H-1152 shows poor inhibition on other serine/threonine kinases.
H-1152 inhibits the phosphorylation of MARCKS in human neuroteratoma (NT-2) cells stimulated by Rho-activator lysophosphatidic acid.

物理化学性质&存储条件

分子量 319.4218
分子式 C16H21N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Isoquinoline, 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-

参考文献

1. Ikenoya M, et al. J Neurochem. 2002 Apr;81(1):9-16.

2. Wang HL, et al. Neuropharmacology. 2013 Jul;70:1-11.

3. Sheikh IA, et al. J Biol Chem. 2013 Jul 12;288(28):20404-15.

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