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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Grazoprevir
Grazoprevir

Chemical Structure : Grazoprevir

CAS No.: 1350514-68-9

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Grazoprevir (MK-5172, MK5172)

货号: PC-25228Not For Human Use, Lab Use Only.

Grazoprevir (MK-5172) is a potent, selective inhibitor of HCV NS3/4A protease with broad activity across genotypes and resistant variants, with Ki values of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively, also inhibits SARS-CoV-2 3CLpro activity.

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2 mg ￥780 In stock
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Grazoprevir (MK-5172) is a potent, selective inhibitor of HCV NS3/4A protease with broad activity across genotypes and resistant variants, with Ki values of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively, also inhibits SARS-CoV-2 3CLpro activity.

物理化学性质&存储条件

分子量 766.91
分子式 C38H50N6O9S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(33R,35S,91R,92R,5S)-5-(tert-Butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide

参考文献

1. Summa V, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.

2. Harper S, et al. ACS Med Chem Lett. 2012 Mar 2;3(4):332-6.

3. Qi Sun, et al. Signal Transduct Target Ther. 2021 May 29;6(1):212.

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