Goflikicept | Anti-IL-1B fusion protein | Probechem Biochemicals

Chemical Structure : Goflikicept

CAS No.: 2416984-26-2

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Goflikicept (RPH-104)

货号: PC-38883Not For Human Use, Lab Use Only.

规格	价格	库存
1 mg	￥4980	In stock
5 mg	￥9980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

Goflikicept (RPH-104) is a heterodimeric fusion protein containing IL-1R1 and IL-1RAcP linked to immunoglobulin heavy chains and is highly selectively binds IL-1B, affecting IL-1B signalling pathways, inhibits widespread inflammation.
Human interleukin-1 receptor accessory protein fragment (21-358, 1-338 in the current sequence) fused via peptidyl linker 339GSGGG343 to a human immunoglobulin G1 Fc fragment (344-570, C-terminal Lys clipped) variant (S>C477, T>W489, K>A532), covalent dimer with human interleukin-1 receptor type 1 fragment (21-333, 1-313 in the current sequence) fused via peptidyl linker 314GSGG318 to a human immunoglobulin G1 Fc fragment (319-545, C-terminal Lys clipped) variant (Y>C447, T>S464, L>A466, F>K503, Y>V505), glycosylated, produced in Chinese hamster ovary (CHO) cells.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility
Chemical Name/SMILES	Goflikicept

参考文献

1. Samsonov M, et al. J Transl Med. 2021 Apr 26;19(1):169.

Goflikicept (RPH-104)

生物&药学活性

物理化学性质&存储条件

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Goflikicept (RPH-104)

生物&药学活性

物理化学性质&存储条件

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