Glovadalen | D1 PAM | Probechem Biochemicals

Chemical Structure : Glovadalen

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Glovadalen (UCB0022, UCB-0022)

货号: PC-28438Not For Human Use, Lab Use Only.

Glovadalen (UCB0022) is a potent, selective, brain-penetrant and orally available dopamine D1 receptor (D1R) positive allosteric modulator (PAM).

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生物&药学活性

Glovadalen (UCB0022) is a potent, selective, brain-penetrant and orally available dopamine D1 receptor (D1R) positive allosteric modulator (PAM).
UCB0022 selectively binds D1Rs with nanomolar affinity and enhanced the potency of dopamine to activate D1Rs by approximately 10-fold.
UCB0022 is inactive at D2, D3 and D4 receptors and marginally active at D5 dopamine receptors at 10 uM.
UCB0022 improved motor disability similar to levodopa but with reduced dyskinesia in MPTP-treated macaque.

物理化学性质&存储条件

分子量	476.40
分子式	C24H27Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dichloro-1-methyl-1H-indazol-4-yl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

参考文献

1. Patent WO2022129356 A1 2022-06-23.

2. Patent WO2021001288 A1.

Glovadalen (UCB0022, UCB-0022)

生物&药学活性

物理化学性质&存储条件

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Glovadalen (UCB0022, UCB-0022)

生物&药学活性

物理化学性质&存储条件

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