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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Influenza Virus-Gliocidin
Gliocidin

Chemical Structure : Gliocidin

CAS No.: 62289-81-0

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Gliocidin (SW106065)

货号: PC-61648Not For Human Use, Lab Use Only.

Gliocidin (SW106065) is a broad influenza virus inhibitor acting via IMP dehydrogenase (IMPDH), also is an apoptosis inducer in MPNST (malignant peripheral nerve sheath tumors) with EC50 of 1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Gliocidin (SW106065) is a broad influenza virus inhibitor acting via IMP dehydrogenase (IMPDH), also is an apoptosis inducer in MPNST (malignant peripheral nerve sheath tumors) with EC50 of 1 uM.
Gliocidin (SW106065) is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD) by NMNAT1 enzyme, targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2), induces cell death in GBM cells with IC50 of 200 nM. 
SW106065 inhibits ATP consumption of sMPNST and other models of MPNST with EC50 of 1 uM, shows no toxicity to normally dividing Schwann cells or mouse embryonic fibroblasts; reduces MPNST burden in a mouse allograft model.CPD A inhibits RNA synthesis of IAV and IBV with EC50 values of 2.3 μM and 2.6 μM, respectively.
SW106065 also displays robust in vitro activity against a broad panel of IAV (H1N1 and H3N2) and IBV strains with median EC50 of 0.2 uM, with no significant cytotoxic effect.
SW106065 inhibits IMP dehydrogenase (IMPDH) and causes strong depletion of the cellular GTP pool.
SW106065 exhibits strongly synergistic effect when combined with another IMPDH inhibitor ribavirin.

物理化学性质&存储条件

分子量 204.247
分子式 C10H8N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(pyridin-3-yl)thiophene-2-carboxamide

参考文献

1. Chau V, et al. Cancer Res. 2014 Jan 15;74(2):586-97.

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