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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Glimepiride
Glimepiride

Chemical Structure : Glimepiride

CAS No.: 93479-97-1

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Glimepiride (HOE-490, HOE490)

货号: PC-28334Not For Human Use, Lab Use Only.

Glimepiride (HOE-490) is a sulfonylurea anti-diabetic compound that blocks the ATP-sensitive potassium channel, binds to inhibits to the sulfonylurea receptor 1 (SUR1/Kir6.2) component of ATP sensitive potassium (K ATP) channels located on pancreatic beta cells, shows binding IC50 of 3.0 nM for SUR1, 5.4 nM for SUR2A and 7.3 nM for SUR2B.

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500 mg ￥380 In stock
1 g ￥580 In stock
5 g ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Glimepiride (HOE-490) is a sulfonylurea anti-diabetic compound that blocks the ATP-sensitive potassium channel, binds to inhibits to the sulfonylurea receptor 1 (SUR1/Kir6.2) component of ATP sensitive potassium (K ATP) channels located on pancreatic beta cells, shows binding IC50 of 3.0 nM for SUR1, 5.4 nM for SUR2A and 7.3 nM for SUR2B.

物理化学性质&存储条件

分子量 490.62
分子式 C24H34N4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Ethyl-4-methyl-N-(4-(N-((rel-(1r,4r)-4-methylcyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

参考文献

1. Hu S, et al. J Pharmacol Exp Ther. 2000 May;293(2):444-52.

2. Gribble FM, et al. Metabolism. 2000 Oct;49(10 Suppl 2):3-6.

3. Song DK, et al. Br J Pharmacol. 2001 May;133(1):193-9.

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