Givinostat (ITF-2357) | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : Givinostat

CAS No.: 497833-27-9

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Givinostat (ITF-2357, ITF2357)

货号: PC-22791Not For Human Use, Lab Use Only.

Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
Givinostat (ITF-2357) has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells.
Givinostat (ITF-2357) reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.
Givinostat (ITF-2357) reduces cytokines and protects islet β cells in vivo and in vitro.

物理化学性质&存储条件

分子量	421.50
分子式	C24H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate

参考文献

1. Li S, et al. J Biol Chem. 2015 Jan 23;290(4):2368-78.

2. Leoni F, et al. Mol Med. 2005 Jan-Dec;11(1-12):1-15.

3. Golay J, et al. Leukemia. 2007 Sep;21(9):1892-900.

4. Guerini V, et al. Leukemia. 2008 Apr;22(4):740-7.

Givinostat (ITF-2357, ITF2357)

生物&药学活性

物理化学性质&存储条件

参考文献

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Givinostat (ITF-2357, ITF2357)

生物&药学活性

物理化学性质&存储条件

参考文献

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