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首页-小分子抑制剂&激动剂-GPCR-Platelet-activating Factor Receptor-Ginkgolide B
Ginkgolide B

Chemical Structure : Ginkgolide B

CAS No.: 15291-77-7

Ginkgolide B (BN-52021)

货号: PC-24430Not For Human Use, Lab Use Only.

Ginkgolide B (BN-52021) is a terpene lactone and a potent platelet activating factor antagonist, also is a spermidine/spermine N1-acetyltransferase 1 (SAT1) inhibitor with Ki of 24.18 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ginkgolide B (BN-52021) is a terpene lactone and a potent platelet activating factor antagonist, also is a spermidine/spermine N1-acetyltransferase 1 (SAT1) inhibitor with Ki of 24.18 uM.
Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics.
Ginkgolide B can pass through the brain-blood barrier.
Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity.
Ginkgolide B attenuates the metastatic tumor burden in mouse models.

物理化学性质&存储条件

分子量 424.40
分子式 C20H24O10
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

参考文献

1. Zheng C, et al. Nat Commun. 2025 Apr 3;16(1):3174.

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