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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-Gambogic Acid
Gambogic Acid

Chemical Structure : Gambogic Acid

CAS No.: 2752-65-0

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Gambogic Acid (Beta-Guttiferrin)

货号: PC-27233Not For Human Use, Lab Use Only.

Gambogic Acid (Beta-Guttiferrin) is a natural product derived from Garcinia hanburyi Hook with anticancer properties, inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, also binds specifically to SHMT2 Cys241, inhibiting SHMT2 enzymatic activity and disrupting mitochondrial function.

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25 mg ￥580 In stock
50 mg ￥880 In stock
100 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Gambogic Acid (Beta-Guttiferrin) is a natural product derived from Garcinia hanburyi Hook with anticancer properties, inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, also binds specifically to SHMT2 Cys241, inhibiting SHMT2 enzymatic activity and disrupting mitochondrial function.

物理化学性质&存储条件

分子量 628.76
分子式 C38H44O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-11H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid

参考文献

1. Zhai D, et al. Mol Cancer Ther. 2008 Jun;7(6):1639-46.

2. Yang T, et al. Adv Sci (Weinh). 2026 Jun 30:e20252.

3. Wang LH, et al. Br J Cancer. 2014 Jan 21;110(2):341-52.

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