GW405833 hydrochloride | CB2 agonist |Probechem Biochemicals

Chemical Structure : GW405833 hydrochloride

CAS No.: 1202865-22-2

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GW405833 hydrochloride (GW-405833, GW 405833)

货号: PC-60728Not For Human Use, Lab Use Only.

GW405833 hydrochloride is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GW405833 hydrochloride is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
GW405833 causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM.
GW405833 elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.

物理化学性质&存储条件

分子量	483.814
分子式	C23H25Cl3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone hydrochloride

参考文献

1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.

2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.

3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.

4. Li AL, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):296-305.

GW405833 hydrochloride (GW-405833, GW 405833)

生物&药学活性

物理化学性质&存储条件

参考文献

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GW405833 hydrochloride (GW-405833, GW 405833)

生物&药学活性

物理化学性质&存储条件

参考文献

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