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首页-小分子抑制剂&激动剂-Others-Other Targets-GT-02216
GT-02216

Chemical Structure : GT-02216

CAS No.: 2648407-76-3

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GT-02216 (GT02216)

货号: PC-24677Not For Human Use, Lab Use Only.

GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models.

物理化学性质&存储条件

分子量 389.46
分子式 C22H23N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6-amino-4-((2-hydroxyphenyl)amino)pyridin-2-yl)(4-phenylpiperazin-1-yl)methanone

参考文献

1. Matteo Ciccaldo, et al. Sci Rep. 2025 May 21;15(1):17646.

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