GSTO1 inhibitor A13

Chemical Structure : GSTO1 inhibitor A13

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货号: PC-25752Not For Human Use, Lab Use Only.

GSTO1 inhibitor A13 is a potent, selective, covalent and metabolically stable glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 457 nM, targets GSTO1 at Cys32.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

GSTO1 inhibitor A13 is a potent, selective, covalent and metabolically stable glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 457 nM, targets GSTO1 at Cys32.
A13 effectively inhibits the release of IL-1β and IL-18, with IC50 values of 1.9 uM and 1.0 uM, respectively, in human PBMC-derived macrophage model.
A13 exhibits modest GSTO1 engagement in both cell-free and cellular CMFDA assays.
A13 inhibits NLRP3 inflammasome–associated IL-1β and IL-18 release in both mouse bone marrow-derived macrophages and human monocyte-derived macrophages.

物理化学性质&存储条件

分子量	353.36
分子式	C16H14F3N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(2-(5-(4-(Trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)pyrrolidin-1-yl)prop-2-en-1-one

参考文献

1. Yanli Sun, et al. J Med Chem. 2025 Nov 13. doi: 10.1021/acs.jmedchem.5c01724.