GSR-3-120 | c-Cbl inhibitor | Probechem Biochemicals

Chemical Structure : GSR-3-120

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GSR-3-120 (Compound 3-120)

货号: PC-26049Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

GSR-3-120 (Compound 3-120) is a specific small molecule inhibitor / antagonist of E3 ubiquitin ligase c-Cbl, inhibits EGFR binding to CBL family proteins and competes with phosphotyrosine 1045 of the EGFR for binding to c-Cbl.
SR-3-120 binds to c-Cbl with an ~10-fold higher affinity than phosphoEGFR, reduces EGFR ubiquitylation by 40%, and increases the magnitude of ligand-stimulated EGFR phosphorylation by 30 to 40%.
SR-3-120 enhances the restoration of corneal epithelial debridement wounds.

物理化学性质&存储条件

分子量	482.97
分子式	C25H27ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-chlorophenethyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)-3-(5-methoxy-2-methyl-1H-indol-3-yl)propanamide

参考文献

1. Tarvestad-Laise K, et al. Proc Natl Acad Sci U S A. 2026 Feb 17;123(7):e2518857123.

GSR-3-120 (Compound 3-120)

生物&药学活性

物理化学性质&存储条件

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GSR-3-120 (Compound 3-120)

生物&药学活性

物理化学性质&存储条件

参考文献

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