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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-GSK805
GSK805

Chemical Structure : GSK805

CAS No.: 1426802-50-7

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GSK805 (GSK-805)

货号: PC-43201Not For Human Use, Lab Use Only.

GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively。
GSK805 demonstrates excellent in vivo efficacy in EAE mice dose dependently.

物理化学性质&存储条件

分子量 532.3596
分子式 C23H18Cl2F3NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-

参考文献

1. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92.

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