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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-GSK467
GSK467

Chemical Structure : GSK467

CAS No.: 1628332-52-4

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GSK467 (GSK-467, GSK 467)

货号: PC-62292Not For Human Use, Lab Use Only.

GSK467 (GSK-467) is a potent, selective KDM5B (JARID1B) inhibitor with Ki of 10 nM and IC50 of 26 nM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK467 (GSK-467) is a potent, selective KDM5B (JARID1B) inhibitor with Ki of 10 nM and IC50 of 26 nM.
GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members.
GSK-467 (GSK467) increases the rate of apoptosis in myeloma cells.

物理化学性质&存储条件

分子量 319.32
分子式 C17H13N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one

参考文献

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.

2. Westaway SM, et al. J Med Chem. 2016 Feb 25;59(4):1370-87.

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