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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-GSK3357679
GSK3357679

Chemical Structure : GSK3357679

CAS No.: 1802987-00-3

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GSK3357679 (GSK-3357679)

货号: PC-25956Not For Human Use, Lab Use Only.

GSK3357679 is a highly potent, selective and brain-penetrant LRRK2 inhibitor with IC50 of 20.0 nM in SHSY5Y cells measuring inhibition of pS935.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GSK3357679 is a highly potent, selective and brain-penetrant LRRK2 inhibitor with IC50 of 20.0 nM in SHSY5Y cells measuring inhibition of pS935.
GSK3357679 demonstrates favorable kinase selectivity and excellent in vitro and in vivo PK profiles in rats and dogs.
GSK3357679 is a useful new in vitro and in vivo tool molecule to investigate the role of LRRK2 in Parkinson's disease in cell and rodent models.

物理化学性质&存储条件

分子量 435.89
分子式 C19H23ClFN7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-chloro-1-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine

参考文献

1. Axten JM, et al. RSC Med Chem. 2025 Nov 17. doi: 10.1039/d5md00856e.

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