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首页-小分子抑制剂&激动剂-Apoptosis-Receptor Interacting Protein Kinase (RIPK)-GSK2983559
GSK2983559

Chemical Structure : GSK2983559

CAS No.: 1579965-12-0

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GSK2983559 (GSK 2983559)

货号: PC-73178Not For Human Use, Lab Use Only.

GSK2983559 is a potent, selective and orally active receptor interacting protein 2 kinase (RIPK2) inhibitor with IC50 of 7 nM.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK2983559 is a potent, selective and orally active receptor interacting protein 2 kinase (RIPK2) inhibitor with IC50 of 7 nM.
GSK2983559 exhibits excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

物理化学性质&存储条件

分子量 538.53
分子式 C21H23N4O7PS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate

参考文献

1. Pamela A Haile, et al. J Med Chem. 2019 Jul 25;62(14):6482-6494.

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