GSK269962A | ROCK inhibitor | Probechem Biochemicals

Chemical Structure : GSK269962A

CAS No.: 850664-21-0

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GSK269962A (GSK269962)

货号: PC-24391Not For Human Use, Lab Use Only.

GSK269962A is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 1.6 nM (recombinant human ROCK1), 30-fold selectivity against a panel of serine/threonine kinases.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK269962A is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 1.6 nM (recombinant human ROCK1), 30-fold selectivity against a panel of serine/threonine kinases.
GSK269962 blocked the generation of inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide-stimulated monocytes.
GSK269962A induced vasorelaxation in preconstricted rat aorta with an IC50 of 39 and 35 nM, respectively.
GSK269962 produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats, induced a reduction in blood pressure of approximately 10, 20, and 50 mm Hg at 1, 3, and 30 mg/kg.

物理化学性质&存储条件

分子量	570.61
分子式	C29H30N8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4, 5-c]pyridin-6-yl]oxy}phenyl)-4-{[2-(4-morpholinyl)ethyl]-oxy}benzamide

参考文献

1. Smith GK, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.

GSK269962A (GSK269962)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK269962A (GSK269962)

生物&药学活性

物理化学性质&存储条件

参考文献

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