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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-GSK235
GSK235

Chemical Structure : GSK235

CAS No.:

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GSK235 (GSK-235)

货号: PC-27081Not For Human Use, Lab Use Only.

GSK235 is a potent, selective and orally available inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1) with biochemical pIC50 of 8.45, shows >1000-fold selectivity over ERAP2/IRAP.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GSK235 is a potent, selective and orally available inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1) with biochemical pIC50 of 8.45, shows >1000-fold selectivity over ERAP2/IRAP.
GSK235 regulates the immunopeptidome of cancer cells, and enhances tumor antigenicity in vivo controlling growth.

物理化学性质&存储条件

分子量 386.50
分子式 C21H30N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4R)-1-(3-cyano-4-methyl-6-((4-methyltetrahydro-2H-pyran-4-yl)amino)pyridin-2-yl)-4-isopropylpyrrolidine-3-carboxylic acid

参考文献

1. Tinworth CP, et al. J Med Chem. 2026 Jun 21. doi: 10.1021/acs.jmedchem.6c00029.

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