GSK1562590 hydrochloride | Urotensin II receptor antagonist

Chemical Structure : GSK1562590 hydrochloride

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GSK1562590 hydrochloride (GSK-1562590 hydrochloride)

货号: PC-28273Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

GSK1562590 hydrochloride is a potent, nonpeptidic antagonist of Urotensin II receptor (UT) with pKi of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native (SJRH30 cells) UT.
GSK1562590 has >100-fold selectivity for UT versus 87 distinct mammalian GPCR, enzyme, ion channel and neurotransmitter uptake targets.
GSK1562590 is an insurmountable UT antagonist in rat, cat and hUT transgenic mouse arteries (pKb= 8.93–10.12 across species).
GSK1562590 inhibited the hU-II-induced systemic pressor response in anaesthetized cats.
GSK1562590 inhibited hU-II-induced contraction of rat aorta.

物理化学性质&存储条件

分子量	617.95
分子式	C30H31Cl3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4'-(1-(2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-N-methylacetamido)-2-(pyrrolidin-1-yl)ethyl)-[1,1'-biphenyl]-3-carboxamide hydrochloride

参考文献

1. Behm DJ, et al. Br J Pharmacol. 2010 Sep;161(1):207-28.

GSK1562590 hydrochloride (GSK-1562590 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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GSK1562590 hydrochloride (GSK-1562590 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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