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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-GSK143
GSK143

Chemical Structure : GSK143

CAS No.: 1240390-27-5

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GSK143 (GSK-143, GSK 143)

货号: PC-63376Not For Human Use, Lab Use Only.

GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70.
GSK143 inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos cells with pIC50 of 7.1, and anti-IgM induced CD69 surface expression in primary B cells with pIC50 of 6.6.
GSK143 shows good efficacy in the rat Arthus model.

物理化学性质&存储条件

分子量 342.396
分子式 C17H22N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)-4-(p-tolylamino)pyrimidine-5-carboxamide

参考文献

1. Liddle J, et al. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94.

2. van Bree SH, et al. Gut. 2013 Nov;62(11):1581-90.

3. Salehi S, et al. PLoS One. 2017 Jan 20;12(1):e0163614.

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