GSK1104252A | GPR119 agonist | Probechem Biochemicals

Chemical Structure : GSK1104252A

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GSK1104252A (GSK-1104252A)

货号: PC-24693Not For Human Use, Lab Use Only.

GSK1104252A is a potent, selective and orally bioavailable GPR119 agonist with pEC50 of 7.3 in reporter assay with the human GPR119 receptor stably expressed in CHO-K1 6CRE-luciferase cells.

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生物&药学活性

GSK1104252A is a potent, selective and orally bioavailable GPR119 agonist with pEC50 of 7.3 in reporter assay with the human GPR119 receptor stably expressed in CHO-K1 6CRE-luciferase cells.
GSK1104252A induces GLP-1 secretion in GluTag cells with a pEC50 of 7.7.
GSK1104252A shows excellent pharmacokinetic properties and sufficient selectivity with in vivo in glucose homeostasis in the rodent.

物理化学性质&存储条件

分子量	478.54
分子式	C22H27FN4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperidinecarboxylic acid, 4-[[7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester

参考文献

1. Katamreddy SR, et al. J Med Chem. 2012 Dec 27;55(24):10972-94.

GSK1104252A (GSK-1104252A)

生物&药学活性

物理化学性质&存储条件

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GSK1104252A (GSK-1104252A)

生物&药学活性

物理化学性质&存储条件

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