GSK-3β inhibitor 47

Chemical Structure : GSK-3β inhibitor 47

CAS No.: 2227316-74-5

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货号: PC-20114Not For Human Use, Lab Use Only.

GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.

规格	价格	库存
2 mg	￥2980	In stock
5 mg	￥4580	In stock
10 mg		Get quote
25 mg		Get quote

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GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.
GSK-3β inhibitor 47 significantly lowered levels of phosphorylated tau in triple-transgenic mouse Alzheimer's disease models.

物理化学性质&存储条件

分子量	414.47
分子式	C23H22N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide

参考文献

1. Richard A. et al. J Med Chem. 2023 Mar 23;66(6):4231-4252.