GS143 | E3 ligase β-TrCP inhibitor | Probechem Biochemicals

Chemical Structure : GS143

CAS No.: 916232-21-8

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GS143 (GS-143)

货号: PC-24524Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

GS143 is a specific small molecule inhibitor of E3 ligase β-TrCP, exhibits potent latency reversing agent (LRA) activity, also is a NF-kappaB signaling inhibitor, inhibits IκBα ubiquitylation (IC50=5.2 uM).
GS143 selectively inhibits IκBα ubiquitination inhibitor withIC50 of 5.2 uM for SCF βTrCP1-mediated IκBα ubiquitylation.
GS143 displays potent LRA activity in a primary cell model of HIV-1 latency.
GS143 triggers a novel signaling pathway to reactivate latent HIV-1 that leads to the unconventional activation of NFκB p65, by initiating the noncanonical signaling via NIK, followed by activation of IKK leading to phosphorylation of p65 on S536 and its nuclear translocation.

物理化学性质&存储条件

分子量	466.47
分子式	C28H19FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

参考文献

1. Sarkar S, et al. PLoS Pathog. 2025 Apr 1;21(4):e1013018.

2. Nakajima H, et al. Biochem Biophys Res Commun. 2008;368(4):1007–13.

GS143 (GS-143)

生物&药学活性

物理化学性质&存储条件

参考文献

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GS143 (GS-143)

生物&药学活性

物理化学性质&存储条件

参考文献

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