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首页-小分子抑制剂&激动剂-Others-Other Targets-GS-1291269
GS-1291269

Chemical Structure : GS-1291269

CAS No.: 2845278-33-1

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GS-1291269 (GS1291269)

货号: PC-26005Not For Human Use, Lab Use Only.

GS-1291269 is a potent, selective and neutral ketohexokinase (KHK) inhibitor, with IC50 of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GS-1291269 is a potent, selective and neutral ketohexokinase (KHK) inhibitor, with IC50 of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively.
GS-1291269 demonstrates a strong PD effect in both kidney and liver tissues with free plasma EC50 values of 3.5 and 2.6 nM, respectively.
GS-1291269 is shown to effectively reduce the levels of F1P in rat liver and kidney tissues upon oral administration.

物理化学性质&存储条件

分子量 474.45
分子式 C20H19F5N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-Amino-3-(4-(7,7-difluoro-2-(2-(trifluoromethyl)azetidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)phenyl)thietane 1,1-Dioxide

参考文献

1. Kasun ZA, et al. J Med Chem. 2026 Jan 8;69(1):501-516.

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