GPX4 inhibitor C18 | GPX4 inhibitor | Probechem Biochemicals

Chemical Structure : GPX4 inhibitor C18

CAS No.: 2922824-09-5

加入收藏

GPX4 inhibitor C18 (GPX4-IN-5)

货号: PC-26934Not For Human Use, Lab Use Only.

GPX4 inhibitor C18 (GPX4-IN-5) is a covalent inhibitor of glutathione peroxidase 4 (GPX4), shows remarkable inhibitory activity against TNBC cells with IC50 of 10-75 nM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GPX4 inhibitor C18 (GPX4-IN-5) is a covalent inhibitor of glutathione peroxidase 4 (GPX4), shows remarkable inhibitory activity against TNBC cells with IC50 of 10-75 nM.
C18 notably induces ferroptosis with high selectivity by increasing the accumulation of lipid peroxides (LPOs) in cells.
C18 covalently binds to the Sec46 of GPX4.
C18 exhibited tumor growth inhibition in the MDA-MB-231 xenograft model with a TGI value of 81.0% at 20 mg/kg without obvious toxicity.

物理化学性质&存储条件

分子量	381.78
分子式	C18H17ClFNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)acetamide

参考文献

1. Tingting Chen, et al. J Med Chem. 2023 Jul 27;66(14):10036-10059.

GPX4 inhibitor C18 (GPX4-IN-5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GPX4 inhibitor C18 (GPX4-IN-5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.